Iran’s Supreme Leader Ayatollah Mojtaba Khamenei warned on Saturday that the United States would face “unforgettable lessons” if its attacks continue, as the conflict deepened with the first reported US troop deaths from direct Iranian fire since the war began.
His written statement, broadcast on Iranian state television, accused Washington of repeatedly violating the memorandum of understanding (MoU) signed last month and said President Donald Trump’s signature was “worthless and invalid.”
The remarks came as both sides continued military operations and declared the agreement effectively collapsed.
The US military said two American service members were killed and another was missing following an Iranian attack on a base in Jordan on Friday.
Four additional service members were medically evacuated to hospitals in Jordan before later being discharged.
According to US Central Command, the attack occurred as US and partner forces defended against ballistic missile and drone strikes.
The military also said its forces carried out a seventh consecutive night of strikes targeting surveillance sites, military logistics infrastructure, underground weapons storage and maritime capabilities.
Since the conflict began, the US said 16 service members have been killed and more than 430 wounded.
Iran’s deputy foreign minister, Kazem Gharibabadi, separately said Tehran was no longer implementing its commitments under the interim MoU, arguing that Washington had violated the agreement.
Khamenei said the United States had “revealed its true face,” while urging Iranians to remain vigilant and trust the country’s leadership during the conflict.
The fighting has increasingly affected regional infrastructure and strategic waterways.
Authorities in Kuwait reported damage to a water desalination plant and an oil facility following Iranian strikes, while Iraq said it intercepted attack drones over Irbil.
Jordan reported downing Iranian missiles, and Bahrain and Saudi Arabia activated air defence measures in response to missile threats.
Reports also suggested Yemen’s Houthis could seek to close the Bab al-Mandeb gateway in support of Iran, potentially adding further pressure to regional security and global energy markets.
The MoU, mediated by Qatar and Pakistan, had been intended to create conditions for a permanent end to the fighting, but both Tehran and Washington now say the agreement has broken down.